CCL4 CLIA Kit for Human(Homo sapiens) | EIAab.comCCL4 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CCL4(Gene name) > Human

CCL4 (Gene name),

C-C motif chemokine 4 (Protein name ), CCL4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CCL4(LAG1;MIP1B;SCYA4);

Protein name:

C-C motif chemokine 4;

Alternative:

T-cell activation protein 2(ACT-2);HC21;G-26 T-lymphocyte-secreted protein;MIP-1-beta(1-69);Lymphocyte activation gene 1 protein(LAG-1);PAT 744;Macrophage inflammatory protein 1-beta(MIP-1-beta);SIS-gamma;Protein H400;Small-inducible cytokine A4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

Function:

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

Sequence:

50:

92:

YYETSSLCSQ | PAVVFQTKRS | KQVCADPSES | WVQEYVYDLE | LN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000250151

Pfam:

PF00048

KEGG:

hsa:388372

UniGene:

Hs.449862

SMR:

P13236

String:

P13236

MIM:

182284

UniGene:

Hs.655293

Uniprot:

P13236

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ELISA Kit for Human C-C motif chemokine 4

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E0093c

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ELISA Kit for Human C-C motif chemokine 4

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E0093h

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ELISA Kit for Human C-C motif chemokine 4

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E0093m

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ELISA Kit for Human C-C motif chemokine 4

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E0093r

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ELISA Kit for Human C-C motif chemokine 4

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E0093p

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ELISA Kit for Human C-C motif chemokine 4

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E0093d

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ELISA Kit for Human C-C motif chemokine 4

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E0093b

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ELISA Kit for Human C-C motif chemokine 4

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CLIA Kit for Human C-C motif chemokine 4

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U0093d

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96T

CLIA Kit for Human C-C motif chemokine 4

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U0093h

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96T

CLIA Kit for Human C-C motif chemokine 4

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U0093m

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96T

CLIA Kit for Human C-C motif chemokine 4

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U0093r

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CLIA Kit for Human C-C motif chemokine 4

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CLIA Kit for Human C-C motif chemokine 4

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U0093c

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CLIA Kit for Human C-C motif chemokine 4

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U0093p

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CLIA Kit for Human C-C motif chemokine 4

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U0093b

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Polyclonal Antibody for Human C-C motif chemokine 4

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P0093Rb-m

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Polyclonal Antibody for Human C-C motif chemokine 4

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P0093Rb-h

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Polyclonal Antibody for Human C-C motif chemokine 4

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P0093Rb-r

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Monoclonal Antibody for Human C-C motif chemokine 4

Protein for Human C-C motif chemokine 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification, cloning, and characterization of an immune activation gene."
Lipes M.A. , Napolitano M. , Jeang K.-T. , Chang N.T. , Leonard W.J.
Proc. Natl. Acad. Sci. U.S.A.85:9704-9708(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors."
Zipfel P.F. , Balke J. , Irving S.G. , Kelly K. , Siebenlist U.
J. Immunol.142:1582-1590(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
Brown K.D. , Zurawski S.M. , Mosmann T.R. , Zurawski G.
J. Immunol.142:679-687(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: T-cell.
4.

"Cloning and expression of a lymphocyte activation gene (LAG-1)."
Baixeras E. , Roman-Roman S. , Jitsukawa S. , Genevee C. , Mechiche S. , Viegas-Pequignot E. , Hercend T. , Triebel F.
Mol. Immunol.27:1091-1102(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Natural killer cell.
5.

"Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes."
Chang H.C. , Reinherz E.L.
Eur. J. Immunol.19:1045-1051(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: T-cell.
6.

"The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization."
Napolitano M. , Modi W.S. , Cevario S.J. , Gnarra J.R. , Seuanez H.N. , Leonard W.J.
J. Biol. Chem.266:17531-17536(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients."
Colobran R. , Adreani P. , Ashhab Y. , Llano A. , Este J.A. , Dominguez O. , Pujol-Borrell R. , Juan M.
J. Immunol.174:5655-5664(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-80
11.

"A novel polypeptide secreted by activated human T lymphocytes."
Miller M.D. , Hata S. , Waal Malefyt R. , Krangel M.S.
J. Immunol.143:2907-2916(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-92;VARIANT THR-80
tissue: T-cell.
12.

"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
Bernardini G. , Hedrick J. , Sozzani S. , Luini W. , Spinetti G. , Weiss M. , Menon S. , Zlotnik A. , Mantovani A. , Santoni A. , Napolitano M.
Eur. J. Immunol.28:582-588(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR INTERACTION
13.

"Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells."
Cocchi F. , DeVico A.L. , Garzino-Demo A. , Arya S.K. , Gallo R.C. , Lusso P.
Science270:1811-1815(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
Garlisi C.G. , Xiao H. , Tian F. , Hedrick J.A. , Billah M.M. , Egan R.W. , Umland S.P.
Eur. J. Immunol.29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Natural truncation of the chemokine MIP-1beta/CCL4 affects receptor specificity but not anti-HIV-1 activity."
Guan E. , Wang J. , Roderiquez G. , Norcross M.A.
J. Biol. Chem.277:32348-32352(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF MIP-1-BETA(3-69) BY MASS SPECTROMETRY;FUNCTION;SUBUNIT
16.

"Macrophage inflammatory protein-1."
Menten P. , Wuyts A. , Van Damme J.
Cytokine Growth Factor Rev.13:455-481(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
17.

"High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR."
Lodi P.J. , Garrett D.S. , Kuscewski J. , Tsang M.L.S. , Weatherbee J.A. , Leonard W.J. , Gronenborn A.M. , Clore G.M.
Science263:1762-1767(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR

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